Goal-directed actions transiently depend on dorsal hippocampus

Laura A. Bradfield, Beatrice K. Leung, Susan Boldt, Sophia Liang, Bernard W. Balleine

Nature Neuroscience

August 2020


The role of the hippocampus in goal-directed action is currently unclear; studies investigating this issue have produced contradictory results. Here we reconcile these contradictions by demonstrating that, in rats, goal-directed action relies on the dorsal hippocampus, but only transiently, immediately after initial acquisition. Furthermore, we found that goal-directed action also depends transiently on physical context, suggesting a psychological basis for the hippocampal regulation of goal-directed action control.