Contributions of intrinsic and extrinsic reward sensitivity to apathy: Evidence from traumatic brain injury.

Halle Quang, Fiona Kumfor, Bernard Balleine, Tuong-Vu Nguyen, Truc-Quynh Nguyen, My-Ngan Nguyen, and Skye McDonald.

Neuropsychology

October 2022

Abstract

Objective: Apathy is a key feature of traumatic brain injury (TBI). However, mechanisms underlying apathy are poorly understood. Evidence suggests that changes in reward may be a crucial factor. Rewards can come from two important sources: extrinsic reward (e.g., money) and intrinsic reward (e.g., enjoyment). Here, we used an experimental paradigm to examine the contributions of intrinsic–extrinsic reward sensitivity to apathy post-TBI and neurocognitive processes associated with these reward processing components. Method: Fifty-seven patients with TBI (TBI with clinical/severe apathy [TBI + sA], TBI with subclinical/moderate apathy [TBI + mA] and TBI without apathy [TBI-A] groups), and 30 healthy individuals completed the “birthday-gift task.” In the “intrinsic reward” condition, participants chose to “go” to collect the gift or “wait” for the same gift to be delivered. In the “extrinsic reward” condition, the task was identical, however, participants received monetary incentives when choosing “going” instead of “waiting.” The Montreal Cognitive Assessment was utilized for cognitive examination. Results: A smaller proportion of people in the TBI + sA group had high sensitivity to both intrinsic and extrinsic rewards than the TBI + mA, TBI-A and healthy comparison groups. The TBI+sA group also perceived the “go” option on the intrinsic reward condition as more effortful and made fewer “go” decisions on the extrinsic condition. Attention was the only predictor of intrinsic reward sensitivity, whereas executive functioning, attention and group predicted extrinsic reward. Conclusion: This study demonstrates the relationship between intrinsic–extrinsic reward hyposensitivity and apathy post-TBI. These results may be integrated into future trials to improve apathy in clinical practice.