I am a PhD candidate interested in the how cognitive processes are impaired as a result of obesity. Using rodent models, my research is currently focused on investigating the role of the insulin receptor, and insulin resistance, in appetitive learning, hippocampal-dependent memory, and decision-making. It aims to outline how dietary induced obesity and subsequent central insulin resistance 1) impacts transport of insulin across the blood-brain barrier and 2) disrupts goal-directed appetitive behaviours. I use Pavlovian-instrumental transfer paradigms, viral techniques, and transgenics to carry out these investigations. More broadly, I am interested in the translation between neuroscientific advances and public health prevention for obesity related/induced dementias and cognitive decline.
Gladding, J. G., Abbott, K. N., Antoniadis, C. P., Stuart, A., and Begg, D. P. (2018) The effect of intrahippocampal insulin infusion on spatial cognitive function and markers of neuroinflammation in diet-induced obesity. Front Endocrinol. Read More.