Elahe Khosrowabadi
PhD Candidate
Education
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Master of Research (Biochemistry), Tarbiat Modares University, Iran (2016)
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Bachelor of Science (Molecular and Cellular Biotechnology), Shahed University, Iran (2012)
Research interests
I am broadly interested in the neural and neurochemical mechanisms that govern adaptive decision-making and behavioral flexibility. My research aims to understand how synaptic plasticity and neuromodulatory systems within cortico-striatal circuits, particularly opioid and dopaminergic signaling, modulate outcome valuation and behavioral control. I am especially interested in how disruptions in these processes impair the integration of predictive and reward-related information, leading to the emergence of compulsive and maladaptive behaviors. By exploring how specific neural populations coordinate action selection, my work seeks to uncover the circuit- and cellular-level mechanisms underlying flexible behavior and its breakdown in conditions such as addiction and neuropsychiatric disorders.
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Karimi-Haghighi, S., Mozafari, R., Chavoshinezhad, S., Khosrowabadi, E., Mahmoudi, M., & Haghparast, A. (2024). A translational approach to using endocannabinoid modulators for targeting the opioid-associated memory. Journal of Current Addiction Reports. Read More.
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Moteshakereh, S. M., Nikoohemmat, M., Farmani, D., Khosrowabadi, E., Salehi, S., & Haghparast, A. (2023). The stress-induced antinociceptive responses in the persistent inflammatory pain involve the orexin receptors in the nucleus accumbens. Journal of Neuropeptides. Read More.
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Mahjoub Navaz, F., Khosrowabadi, E., Latifi, S., Kazem, Y. D., Soltani, J. G., Khalilpour, H., & Soleymani, F. (2022). Effect of low-intensity transcranial magnetic stimulation on response inhibition of adult ADHD. Journal of Basic and Clinical Neuroscience, 13(3), 45–58. Read More.
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Amirteymori, H., Karimi-Haghighi, S., Mirmohammadi, M., Majidinezhad, M., Khosrowabadi, E., & Haghparast, A. (2022). Hypocretin/orexin system in the nucleus accumbens as a promising player in the extinction and reinstatement of methamphetamine-induced CPP. Neuropsychopharmacology Reports, 42(1), 89–104. Read More.
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Khosrowabadi, E., Karimi-Haghighi, S., Jamali, S., & Haghparast, A. (2020). Differential roles of intra-accumbal orexin receptors in acquisition and expression of methamphetamine-induced conditioned place preference in the rats. Neurochemical Research, 45(10), 2310–2325. Read More.
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Khosrowabadi, E., Takalloo, Z., Sajedi, R. H., & Khajeh, K. (2018). Improving the soluble expression of aequorin in Escherichia coli using the chaperone-based approach by co-expression with artemin. Preparative Biochemistry and Biotechnology, 48(8), 732–740. Read More.