Research interests
My research is focussed on understanding the neurobiological basis of psychiatric disorders. I am particularly interested in using animal models of relevance to schizophrenia to understand how dopaminergic dysfunction in this disorder contributes to schizophrenia-relevant behaviours including cognitive deficits. To answer this question, I have used a range of sophisticated techniques which range from behavioural testing and ex vivo molecular biology to in vivo neuroimaging in rodents using positron emission tomography. I am also interested in using animal models to trial novel compounds for treatment. I am especially interested in compounds which could be used as interventions at early stages of the disorder, to delay or prevent disorder onset. Currently I am assessing the contribution of different cortio-striatal pathways on behaviours which are relevant to psychiatric disorders including schizophrenia but also obsessive-compulsive disorder (OCD).
PUBLICATIONs
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Petty, A., Garcia-Hidalgo, A., Halff, E. F., Natesan, S., Withers, D. J., Irvine, E. E., Kokkinou, M., Wells, L. A., Bonsall, D. R., Tang, S. P., Veronese, M., & Howes, O. D. (2023). Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study. Molecular imaging and biology, 25(6), 1054–1062. Read More.
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Petty, A., Glass, L. J., Rothmond, D. A., Purves-Tyson, T., Sweeney, A., Kondo, Y., Kubo, S., Matsumoto, M., & Weickert, C. S. (2022). Increased levels of a pro-inflammatory IgG receptor in the midbrain of people with schizophrenia. Journal of neuroinflammation, 19(1), 188. Read More.
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Petty, A., Howes, O., & Eyles, D. (2021). Animal Models of Relevance to the Schizophrenia Prodrome. Biological psychiatry global open science, 3(1), 22–32. Read More.
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Petty, A., Cui, X., Ali, A., Du, Z., Srivastav, S., Kesby, J. P., Kirik, D., Howes, O., & Eyles, D. (2021). Positive symptom phenotypes appear progressively in "EDiPS", a new animal model of the schizophrenia prodrome. Scientific reports, 11(1), 4294. Read More.
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Petty, A., Cui, X., Tesiram, Y., Kirik, D., Howes, O., & Eyles, D. (2019). Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): a new animal model of relevance to schizophrenia. NPJ schizophrenia, 5(1), 6. Read More.
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Cui, X., Gooch, H., Petty, A., McGrath, J. J., & Eyles, D. (2017). Vitamin D and the brain: Genomic and non-genomic actions. Molecular and cellular endocrinology, 453, 131–143. Read More.
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Ferguson, L., Petty, A., Rohrscheib, C., Troup, M., Kirszenblat, L., Eyles, D. W., & van Swinderen, B. (2017). Transient Dysregulation of Dopamine Signaling in a Developing Drosophila Arousal Circuit Permanently Impairs Behavioral Responsiveness in Adults. Frontiers in psychiatry, 8, 22. Read More.